Pten Cell Autonomously Modulates the Hematopoietic Stem Cell Response to Inflammatory Cytokines
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چکیده
منابع مشابه
Pten Cell Autonomously Modulates the Hematopoietic Stem Cell Response to Inflammatory Cytokines
Pten negatively regulates the phosphatidylinositol 3-kinase (PI3K) pathway and is required to maintain quiescent adult hematopoietic stem cells (HSCs). Pten has been proposed to regulate HSCs cell autonomously and non-cell autonomously, but the relative importance of each mechanism has not been directly tested. Furthermore, the cytokines that activate the PI3K pathway upstream of Pten are not w...
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ژورنال
عنوان ژورنال: Stem Cell Reports
سال: 2016
ISSN: 2213-6711
DOI: 10.1016/j.stemcr.2016.04.008